Common interactions with calcineurin inhibitors
Common interactions with calcineurin inhibitors The calcineurin inhibitors (CNIs), tacrolimus and ciclosporin, both metabolised by the enzyme CYP3A4 and P-glycoprotein, will be the first-line medications that are immunosuppressant to stop organ rejection 15. Drug–drug interactions can cause changes that are significant bloodstream plasma amounts and mainly happen when medicines…